Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine.

  title={Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine.},
  author={Colin M. Gelder and Rob Lambkin and Keith W Hart and Douglas Fleming and Oliver M. Williams and Mike Bunce and Kenneth I. Welsh and Sara E F Marshall and J Wade Oxford},
  journal={The Journal of infectious diseases},
  volume={185 1},
Influenza remains a major cause of morbidity and mortality, particularly in at-risk groups where vaccination reduces complications of infection but is not universally protective. In order to determine whether human leukocyte antigen (HLA) class II polymorphisms modulate anti-influenza antibody responses to vaccination, a cohort of HLA-typed at-risk donors was investigated. The subjects were recruited from a single urban family practice. Hemagglutination-inhibition (HAI) titers were measured… CONTINUE READING
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