Associations between high factor VIII and low free protein S levels with traditional arterial thrombotic risk factors and their risk on arterial thrombosis: Results from a retrospective family cohort study

@article{Mulder2010AssociationsBH,
  title={Associations between high factor VIII and low free protein S levels with traditional arterial thrombotic risk factors and their risk on arterial thrombosis: Results from a retrospective family cohort study},
  author={Ren{\'e} Mulder and Inge M. van Schouwenburg and Bakhtawar Khan Mahmoodi and Nic J. G. M. Veeger and Andr{\'e} B. Mulder and Saskia Middeldorp and Hanneke C Kluin-Nelemans and Willem M. Lijfering},
  journal={Thrombosis research},
  year={2010},
  volume={126 4},
  pages={
          e249-54
        }
}
INTRODUCTION Whether high factor (F)VIII and low free protein S levels are risk factors for arterial thrombosis is unclarified. MATERIAL AND METHODS In a post-hoc analysis of a single-centre retrospective family cohort, we determined if these two proteins could increase the risk of arterial thrombosis. In total, 1399 relatives were analysed. RESULTS Annual incidence in relatives with high FVIII levels was 0.29% (95%CI, 0.22-0.38) compared to 0.13% (95%CI, 0.09-0.19) in relatives with normal… CONTINUE READING
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