Associations between clinically diagnosed testicular hypofunction and systemic lupus erythematosus: a record linkage study

@article{Pakpoor2017AssociationsBC,
  title={Associations between clinically diagnosed testicular hypofunction and systemic lupus erythematosus: a record linkage study},
  author={J. Pakpoor and R. Goldacre and M. Goldacre},
  journal={Clinical Rheumatology},
  year={2017},
  volume={37},
  pages={559 - 562}
}
Systemic lupus erythematosus (SLE) has a high female predominance with a 9:1 female-to-male sex ratio, but males have poorer clinical outcomes than females. Gonadal hormones may mediate gender differences in SLE, but their role in SLE remains largely uncharacterised. We aimed to investigate a potential association between testicular hypofunction (TH), as a proxy for low testosterone levels, and SLE in males. A retrospective cohort study was conducted by analysing linked English national… Expand
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