Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study.

@article{Fleisher2015AssociationsBB,
  title={Associations between biomarkers and age in the presenilin 1 E280A autosomal dominant Alzheimer disease kindred: a cross-sectional study.},
  author={A Steven Fleisher and Kewei W Chen and Yakeel T. Quiroz and Laura J Jakimovich and Madelyn Gutierrez Gomez and Carolyn M Langois and Jessica B. S. Langbaum and Auttawut Roontiva and Pradeep Thiyyagura and Wendy Lee and Napatkamon Ayutyanont and Liliana L{\'o}pez and Soledad Gonz{\'a}lez Moreno and Claudia C Mu{\~n}oz and Victoria Tirado and Natalia Acosta-Baena and Anne M. Fagan and Margarita Rosa Giraldo and Gloria Gonz{\'a}lez Garc{\'i}a and Matthew J. Huentelman and Pierre N. Tariot and Francisco Lopera and Eric M. Reiman},
  journal={JAMA neurology},
  year={2015},
  volume={72 3},
  pages={316-24}
}
IMPORTANCE Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1)E280A mutation carriers and noncarriers from the world's largest known autosomal dominant Alzheimer disease (AD) kindred. OBJECTIVE To characterize and compare age-associated changes in brain imaging and fluid biomarkers in PSEN1 E280A mutation carriers and noncarriers. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional measures of 18F-florbetapir positron emission… CONTINUE READING

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