Associations between amyloid β and white matter hyperintensities: A systematic review

@article{Roseborough2017AssociationsBA,
  title={Associations between amyloid $\beta$ and white matter hyperintensities: A systematic review},
  author={Austyn D. Roseborough and Joel Ramirez and Sandra E. Black and Jodi D. Edwards},
  journal={Alzheimer's \& Dementia},
  year={2017},
  volume={13},
  pages={1154-1167}
}
Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation.
White matter alterations in Alzheimer’s disease without concomitant pathologies
TLDR
This study analyses oligodendrocyte and myelin markers in the frontal WM in a series of AD cases without clinical or pathological co‐morbidities.
Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC‐PET Study
TLDR
A modest positive relationship between white matter hyperintensity and elevated amyloid in older adults without dementia is suggested, although the results indicate that this association is nonsignificantly stronger among Black participants, these findings will need to be confirmed or refuted using larger multiracial cohorts.
Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals.
TLDR
Since SVD is associated with longitudinal Aβ1-42 pathology, and the interaction of both factors is linked to poorer cognitive outcomes, the mitigation of SVD may be correlated with reduced amyloid pathology and milder cognitive deterioration in Alzheimer's disease.
Brain amyloid β, cerebral small vessel disease, and cognition
TLDR
Higher global SUVR was associated with worse cognition in CIND and AD, but was augmented by an interaction betweenglobal SUVR and WMH only in Cind, which suggests that Aβ and CSVD are independent processes with a possible synergistic effect between Aβand WMH in individuals with CIND.
White matter hyperintensities are associated with subthreshold amyloid accumulation
Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease
TLDR
These cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration and highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter.
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