Associations between amyloid β and white matter hyperintensities: A systematic review

  title={Associations between amyloid $\beta$ and white matter hyperintensities: A systematic review},
  author={Austyn D. Roseborough and Joel Ramirez and Sandra E. Black and Jodi D. Edwards},
  journal={Alzheimer's \& Dementia},
Small vessel disease lesion type and brain atrophy: The role of co‐occurring amyloid
It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co‐occurring Alzheimer's disease pathology affects this relation.
White matter alterations in Alzheimer’s disease without concomitant pathologies
This study analyses oligodendrocyte and myelin markers in the frontal WM in a series of AD cases without clinical or pathological co‐morbidities.
Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC‐PET Study
A modest positive relationship between white matter hyperintensity and elevated amyloid in older adults without dementia is suggested, although the results indicate that this association is nonsignificantly stronger among Black participants, these findings will need to be confirmed or refuted using larger multiracial cohorts.
Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals.
Since SVD is associated with longitudinal Aβ1-42 pathology, and the interaction of both factors is linked to poorer cognitive outcomes, the mitigation of SVD may be correlated with reduced amyloid pathology and milder cognitive deterioration in Alzheimer's disease.
Brain amyloid β, cerebral small vessel disease, and cognition
Higher global SUVR was associated with worse cognition in CIND and AD, but was augmented by an interaction betweenglobal SUVR and WMH only in Cind, which suggests that Aβ and CSVD are independent processes with a possible synergistic effect between Aβand WMH in individuals with CIND.
White matter hyperintensities are associated with subthreshold amyloid accumulation
Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease
These cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration and highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter.


Cerebral amyloid angiopathy burden associated with leukoaraiosis: A positron emission tomography/magnetic resonance imaging study
Amyloid burden measured by Pittsburgh compound B retention on positron emission tomography (PiB PET) would correlate with the extent of magnetic resonance imaging (MRI) white matter hyperintensities (WMH; or leukoaraiosis) in patients with high vascular amyloid deposition but not in Patients with high parenchymal amyloids deposition or in healthy elderly (HE) subjects.
White matter lesion load is associated with resting state functional MRI activity and amyloid pet but not FDG in mild cognitive impairment and early alzheimer's disease patients
To quantify and investigate the interactions between multimodal MRI/positron emission tomography (PET) imaging metrics in elderly patients with early Alzheimer's disease (AD), mild cognitive
White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?
White matter hyperintensities contribute to the presentation of AD and, in the context of significant amyloid deposition, may provide a second hit necessary for the clinical manifestation of the disease.
Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment
This work tested the hypothesis that lobar and deep CMBs are due to cerebral amyloid angiopathy and deep SVD, respectively, using structural magnetic resonance imaging (MRI) markers of subcortical SVD and in vivo imaging of amyloids in patients with cognitive impairment.
Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients
Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
Cognitive reserve as measured by educational/occupational level and mid/late-life cognitive activity seems to offset the deleterious effects of both pathologies on cognitive trajectories.
White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network
This work examined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers to determine the extent to which WMH manifest in individuals genetically determined to develop AD.
Periventricular hyperintensities are associated with elevated cerebral amyloid
Investigation of the association between periventricular white mater hyperintensities (PVWMH) and biomarkers of elevated cerebral β-amyloid in the Alzheimer's Disease Neuroimaging Initiative found increased PVWMH were associated with elevated cerebral amyloid independent of potential confounders such as age, APOE genotype, and vascular risk factors.
White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia
Evaluated the divergent topography of WM microstructural changes in patients with pure AD and SVaD to eliminate the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease pathologies.