Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement

@article{Carey2016AssociationsBP,
  title={Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement},
  author={Caitlin E. Carey and Arpana Agrawal and Kathleen K. Bucholz and Sarah M. Hartz and Michael T Lynskey and Elliot C. Nelson and Laura J. Bierut and Ryan Bogdan},
  journal={Frontiers in Genetics},
  year={2016},
  volume={7}
}
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 non-Hispanic European–American participants from the Study of Addiction: Genetics and Environment. Polygenic risk… 

Figures and Tables from this paper

Relationships between substance abuse/dependence and psychiatric disorders based on polygenic scores
TLDR
The findings indicate that SUDs share genetic susceptibility with SCZ to a greater extent than with other psychiatric disorders, including externalizing disorders such as attention‐deficit/hyperactivity disorder.
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence
TLDR
Significant evidence was observed for an association between the MDD polygenic risk score (PRS) and AD in the 4 independent genome-wide association study (GWAS) data sets, with stronger evidence for association after meta-analysis of the 4 samples.
EXPLORATORY ANALYSIS OF POLYGENIC RISK SCORES FOR PSYCHIATRIC DISORDERS: APPLIED TO DUAL DIAGNOSIS.
TLDR
It is found that dual diagnosis had a shared genetic susceptibility with major depressive disorder (MDD) and SCZ; furthermore, in individuals with BD, dual diagnosis could be predicted by PRS for MDD.
Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia
TLDR
It is suggested that comorbidity between schizophrenia and substance use disorder is partially attributable to shared polygenic liability, which is most consistent with a general risk for Substance use disorder rather than specific risks for individual substance use disorders.
Polygenic Risk Scores for Psychiatric Disorders Reveal Novel Clues About the Genetics of Disordered Gambling
TLDR
Whether gambling and DG are associated with PRSs for four psychiatric conditions found to be comorbid with DG in epidemiologic surveys is investigated and features common to both SCZ and DG might generate valuable clues about the genetically influenced liabilities to DG.
No evidence of associations between genetic liability for schizophrenia and development of cannabis use disorder
TLDR
The polygenic risk scores for schizophrenia was not associated with CUD in controls or patients with other psychiatric disorders than schizophrenia, speaking against the hypothesis that shared genetic vulnerability would explain the association between cannabis and schizophrenia.
Genetic overlap and causality between substance use disorder and attention‐deficit and hyperactivity disorder
TLDR
A common genetic background between ADHD and SUD is confirmed and support the current literature on the causal effect of the liability to ADHD on the risk for SUD and the need to control for substance use in ADHD is highlighted.
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates
TLDR
A common genetic factor partly explains susceptibility for alcohol, tobacco, cannabis, and opioid use disorder and has a unique genetic architecture that is not shared with normative substance use or non-substance psychopathology, suggesting that addiction is not the linear combination of substance use and psychopathology.
The Addiction Genetic Factor a(g): A Unitary Genetic Vulnerability Characterizes Substance Use Disorders and Their Associations with Common Correlates
TLDR
Shared genetic liability to PAU, PTU, CUD, and OUD was characterized by a unidimensional addiction factor (termed a(g), independent of substance use, suggesting that addiction is not the linear combination of Substance use and psychopathology.
...
...

References

SHOWING 1-10 OF 91 REFERENCES
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Genome-wide association study of comorbid depressive syndrome and alcohol dependence
TLDR
Results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone.
The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.
TLDR
The underlying structure of the genetic and environmental risk factors for the common psychiatric and drug abuse disorders in men and women is very similar.
Psychiatric ‘diseases’ versus behavioral disorders and degree of genetic influence
TLDR
Among psychiatric disorders, there is no close relationship between the strength of genetic influences and the etiologic importance of volitional processes, and many behavioral disorders seem to be more heritable than conditions commonly construed as diseases.
Cannabis controversies: how genetics can inform the study of comorbidity.
TLDR
Overlapping genetic influences underlie the association between early-onset cannabis use and other illicit drug use as well as depression and suicide.
Association of substance dependence phenotypes in the COGA sample
TLDR
The results of this study provide evidence that there are common variants that contribute to the risk for a general liability to substance dependence.
ADHD symptoms, autistic traits, and substance use and misuse in adult Australian twins.
TLDR
Greater ADHD symptoms and autistic traits scores were associated with elevated levels of regular smoking; cannabis use; and nicotine, alcohol, and cannabis use disorders, even after conduct disorder was adjusted for.
The genetics of addiction—a translational perspective
TLDR
There is a need for a multi-method translational approach to genetic studies of these important conditions, including both licit and illicit drug addictions and the behavioral addiction of disordered gambling.
...
...