Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population

@article{Li2015AssociationsBN,
  title={Associations between NBS1 Polymorphisms and Colorectal Cancer in Chinese Population},
  author={Jingtao Li and Bao-yuan Zhong and Hui-Hui Xu and Sheng-Yan Qiao and Gui Wang and Jing Huang and Huizhen Fan and Hong-chuan Zhao},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
As the central protein of the double strand breaks (DSB)-induced DNA repair pathway, NBS1 participates in detecting the DSBs and plays an essential role in maintaining genomic stability. Single nucleotide polymorphisms (SNPs) in NBS1 gene were commonly tested that associated with the susceptibility to multiple cancers, but the results remained controversial. Thus, we conducted two independent hospital-based case–control studies comprising 1,072 colorectal cancer patients and 1,263 controls to… Expand
NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma
TLDR
Findings indicate that rs2735383G > C polymorphism in NBS1 may play a crucial role in the development of laryngeal carcinoma. Expand
The miRNA binding site SNP in the 3′ UTR of NBS1 is inversely associated with breast cancer risk
TLDR
The rs2735383 variant may be a genetic modifier for breast cancer development in Iranians by performing a case–control study in an Iranian population. Expand
rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
TLDR
This study does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility, and subgroup analyses by age, age at menarche, ages at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status did not reveal a significant association. Expand
A non-synonymous polymorphism in NBS1 is associated with progression from chronic hepatitis B virus infection to hepatocellular carcinoma in a Chinese population
TLDR
Findings suggest that, as a non-synonymous SNP, the rs1805794 C/G polymorphism may play a role in the progression from CHB to HCC. Expand
Genetic Polymorphisms of DNA Repair Pathways in Sporadic Colorectal Carcinogenesis
TLDR
Recent insights into the polymorphisms of DNA repair pathway genes, not only individual gene polymorphism but also gene-gene and gene-environment interactions, in sporadic colorectal carcinogenesis are reviewed. Expand
Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort
TLDR
The results have shown that rs7963551 G/T heterozygotes exhibit a significantly increased hazard of death when compared with the combined GG and TT homozygotes, indicating that the SNP affecting efficiency of DSB repair may influence aging in humans. Expand
Digital gene expression profiling analysis of DNA repair pathways in colon cancer stem population of HT29 cells
TLDR
Investigation of the mRNA level of DNA repair genes of colon CSCs from the HT29 cell line in response to single-strand damage and double-Strand breaks reveals that colon C SCs bear efficient DNA repair abilities, which might explain the survival of colonCSCs after repeated chemical and radiation therapy. Expand
DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications.
TLDR
In this review, colorectal cancer and its molecular pathology as well as DNA damage response is briefly introduced and the involvement of key components of this network in the initiation/progression, prognosis, response to treatment and development of drug resistance is comprehensively discussed. Expand
rs 2735383 , located at a microRNA binding site in the 3 ’ UTR of NBS 1 , is not associated with breast cancer risk
Publisher rights © 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in theExpand
The Role of Noncoding RNAs in Genome Stability and Aging
TLDR
This chapter will introduce the current information on various short and long ncRNAs involved in the regulation of genome stability and aging by focusing on eukaryotes. Expand
...
1
2
...

References

SHOWING 1-10 OF 54 REFERENCES
Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma
TLDR
Findings suggest that E185Q polymorphism in NBS1 may be a genetic modifier for the occurrence and aggression of NPC. Expand
Association between the NBS1 Glu185Gln polymorphism and breast cancer risk: a meta-analysis
TLDR
The meta-analysis of currently available data shows no association between the NBS1 Glu185Gln polymorphism and breast cancer risk and subgroup analyses by ethnicity and source of controls did not identify any appreciable relationship of the Nbs1 GLU185GlN polymorphism with breast cancer susceptibility in any populations. Expand
Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years.
TLDR
It is suggested that NBS1 polymorphisms and haplotype-tagging polymorphisms may contribute to the etiology of sporadic breast cancer in young non-Hispanic white women. Expand
DNA repair system and prostate cancer progression: the role of NBS1 polymorphism (rs1805794).
TLDR
The results suggest for the first time that rs1805794 GG genotype appears to be associated with a higher risk for advanced prostate cancer, thus, suggesting a possible new role for NBS1 in prostate cancer progression. Expand
Single nucleotide polymorphisms in breast cancer.
TLDR
It is concluded that within statistical power of the present study, none of the tested polymorphisms associated with BC, with the probable exception of XPD, are associated withBC. Expand
Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
TLDR
This study implicates variants of genes in the double-strand break repair pathway in the etiology of premenopausal breast cancer. Expand
[Study on the association between DNA double-strand break repair gene NBS1 polymorphisms and susceptibility on lung cancer].
TLDR
The G/G genotype at NBS1 rs1805794 site and the Hap4-GC haplotype and Hap 4/Hap2 di haplotype from rs18 05794 and rs2735383 were both associated with lung cancer. Expand
Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.
TLDR
The results show that the genetic variation in XR CC1, XRCC3 and NBS1 influence lung cancer susceptibility among women, and that combinations of risk alleles in the two HR genes can enhance the effects. Expand
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review).
TLDR
There was also some evidence that genetic polymorphisms in certain carcinogen-metabolizing enzymes such as CYP2E1, CYP1A1, CyP2A6, GSTM1, and GSTP1 modulate risk of the cancer, although the results require confirmation with larger sample size studies. Expand
Functional variants in NBS1 and cancer risk: evidence from a meta-analysis of 60 publications with 111 individual studies.
TLDR
It was found that rs2735383 variant genotypes were associated with significantly increased overall risk of cancer under the recessive genetic model, and the I171V, 657del5 and R215W are low-penetrance risk factors for cancer development. Expand
...
1
2
3
4
5
...