Associations among IRS 1 , IRS 2 , IGF 1 , and IGFBP 3 Genetic Polymorphisms and Colorectal Cancer

@inproceedings{Slattery2004AssociationsAI,
  title={Associations among IRS 1 , IRS 2 , IGF 1 , and IGFBP 3 Genetic Polymorphisms and Colorectal Cancer},
  author={Martha L. Slattery and Wade S. Samowitz and Karen Curtin and Khe Ni Ma and Michael Hoffman and Bette Jane Caan and Susan L. Neuhausen},
  year={2004}
}
Introduction: Insulin, insulin-like growth factor (IGF), and IGF binding protein (IGFBP) are involved in cell growth and proliferation and are thought to be important in the etiology of colorectal cancer. We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway. Methods: Data from a population-based incident casecontrol study of 1,346 colon cancer… CONTINUE READING
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An evaluation of energy intake, energy expenditure, and BMI: energy balance and rectal cancer

  • ML Slattery, J Benson, M. Murtaugh
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