Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population

Abstract

Previous studies suggested that cytochrome P450 participated in the tumor metastasis and migration. CYP2B6 also acts as an important enzyme which metabolize partially or primarily metabolism of drugs, environmental contaminants, and mutagens. The objective of this study was to investigate the influence of CYP2B6 polymorphism on susceptibility of Hirschsprung disease. TaqMan assay was performed to determine the genotypes of CYP2B6 rs707265, rs1042389, rs2054675 in 262 cases and 290 control subjects. Logistic regression was used to assess the associations between these polymorphisms and HSCR. We observed a significant association of CYP2B6 rs707265 (G>A) polymorphism and HSCR susceptibility (p < 0.001). Besides, rs707265 A presented a significant risk of HSCR (p < 0.001). Our result suggested that CYP2B6 rs707265 modified the risk of HSCR.

DOI: 10.1007/s10620-014-3450-6

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@inproceedings{Xu2014AssociationsBC, title={Associations Between CYP2B6 rs707265, rs1042389, rs2054675, and Hirschsprung Disease in a Chinese Population}, author={Chao Xu and Pingfa Chen and Hua Xie and Hairong Zhu and Dongmei Zhu and Peng Cai and Weiwei Huo and Yufeng Qin and Hongxing Li and Yankai Xia and Weibing Tang}, booktitle={Digestive Diseases and Sciences}, year={2014} }