Association within a family of a balanced autosomal translocation with major mental illness

@article{Clair1990AssociationWA,
  title={Association within a family of a balanced autosomal translocation with major mental illness},
  author={D. Clair and D. Blackwood and W. Muir and M. Walker and A. Carothers and G. Spowart and C. Gosden and H. Evans},
  journal={The Lancet},
  year={1990},
  volume={336},
  pages={13-16}
}
282 pedigrees in the MRC Cytogenetics Registry, Edinburgh, with familial autosomal anomalies were examined for the presence of associated mental illness. In one large pedigree there were 23 cases of mental and/or behavioural disorders meeting Research Diagnostic Criteria. 34 of the 77 family members available for cytogenetic analysis carried a balanced translocation t(1:11) (q43,q21). Psychiatric diagnoses had been recorded for 16 of the 34 members with the translocation compared with only 5 of… Expand
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