Association with Hrs is required for the early endosomal localization, stability, and function of STAM.

@article{Mizuno2004AssociationWH,
  title={Association with Hrs is required for the early endosomal localization, stability, and function of STAM.},
  author={Emi Mizuno and Kensuke Kawahata and Aya Okamoto and Naomi Kitamura and Masayuki Komada},
  journal={Journal of biochemistry},
  year={2004},
  volume={135 3},
  pages={385-96}
}
Members of the STAM family of proteins, STAM1 and STAM2, are associated with Hrs through their coiled-coil regions. Both Hrs and STAM bind ubiquitin and are involved in endosomal sorting of ubiquitinated cargo proteins for trafficking to the lysosome. Here we examined the biological significance of STAM binding to Hrs. Endogenous STAM1 and STAM2 were mostly localized on the early endosome, suggesting that they are resident endosomal proteins. A STAM2 mutant that lacks the coiled-coil region and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…