Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.

@article{Florez2005AssociationTO,
  title={Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.},
  author={Jose C Florez and Christina M. Agapakis and No{\"e}l P. Burtt and Maria W. Sun and Peter Almgren and Lennart R{\aa}stam and Tiinamaija Tuomi and Daniel Gaudet and Thomas J. Hudson and Mark J. Daly and Kristin G. Ardlie and Joel Hirschhorn and Leif Groop and David Altshuler},
  journal={Diabetes},
  year={2005},
  volume={54 6},
  pages={1884-91}
}
Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated common sequence variants in PTPN1 with type 2 diabetes and diabetes-related phenotypes. We sought to… CONTINUE READING

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