Association study of the vitamin D: 1alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population.

@article{Malecki2003AssociationSO,
  title={Association study of the vitamin D: 1alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population.},
  author={Maciej T Malecki and Tomasz Klupa and Pawel P. Wolkow and Jacek P Bochenski and Krzysztof Wanic and Jacek Sieradzki},
  journal={Diabetes & metabolism},
  year={2003},
  volume={29 2 Pt 1},
  pages={119-24}
}
OBJECTIVES Type 2 diabetes mellitus (T2DM) is a complex disease. Genetic and environmental factors cooperate together to form its clinical picture. Polymorphisms in genes involved in the metabolism of vitamin D may influence susceptibility to T2DM. One of them is the vitamin D 1alpha-hydroxylase (CYP1alpha) gene. In this study we searched for the association of two markers, one in its intron 6 and the another one located upstream from the 5' end of CYP1alpha gene, with T2DM in a Polish… CONTINUE READING