Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population

@article{Matsushita2010AssociationSO,
  title={Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population},
  author={Tomonaga Matsushita and Junji Umeno and Yoichiro Hirakawa and Koji Yonemoto and Kyota Ashikawa and Hanae Amitani and Toshiharu Ninomiya and Jun Hata and Yasufumi Doi and Takanari Kitazono and Mitsuo Iida and Yusuke Nakamura and Yutaka Kiyohara and Michiaki Kubo},
  journal={Journal of Human Genetics},
  year={2010},
  volume={55},
  pages={473-476}
}
Recent genome-wide association study using four prospective population-based cohorts identified two single-nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579, to be significantly associated with the incidence of atherothrombotic stroke. To examine the association of these SNPs with atherothrombotic stroke in the Japanese population, we carried out a case–control association study using a total of 3784 cases and 3102 controls. We also examined the effect of these SNPs… CONTINUE READING
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