• Corpus ID: 26035557

Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.

  title={Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.},
  author={Masaki Mita and Kazuaki Miyake and Masako Zenibayashi and Yushi Hirota and Tetsuya Teranishi and Kunichi Kouyama and Kazuhiko Sakaguchi and Masato Kasuga},
  journal={The Kobe journal of medical sciences},
  volume={54 4},
Mutations of WFS1 gene cause Wolfram syndrome, which is a rare autosomal recessive disorder characterized by juvenile diabetes mellitus, optic atrophy, deafness and diabetes insipidus. The product encoded by WFS1 gene, wolframin, could be involved in ER stress response causing beta-cell loss through impaired cell cycle progression and increased apoptosis. Recently, polymorphisms in the WFS1 gene were strongly associated with type 2 diabetes in Caucasians. The aim of the present study was to… 
A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.
Disease-associated variants of WFS1 contribute to the pathogenesis of T2D through impaired insulin response to glucose stimulation and altered β-cell function.
Association of rs 734312 and rs 10010131 polymorphisms in WFS 1 gene with type 2 diabetes mellitus : a meta-analysis
Recently, many studies have investigated the association of allelic variants of Wolfram syndrome gene (WFS1) with insulin secretion, insulin sensitivity and the risk of hyperglycemia and type 2
Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis.
Investigation of association of WFS1 genes polymorphisms (rs734312 and rs10010131) with T2D by conducting a meta-analysis suggested that the G allele of rs734 312 polymorphism in W FS1 gene had significant protective effects on risk of T1D.
Association of Common Variants of CDKN2A/2B Rs10811661 (C/T) and WFS1 Rs6446482 (C/G) to Type 2 Diabetes Mellitus in the Indian Population of Eastern Uttar Pradesh
This study replicates the association of well established common variants of CDKN2A/2B rs10811661 (C/T) and WFS1 rs6446482 (C-G) with type 2 diabetes in the population of Eastern Uttar Pradesh, India.
Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis.
The results showed that the rs7903146 T allele of the TCF7L2 gene was positively correlated with an enhanced risk of T2DM in the allelic, heterozygote, homozygotes, dominant, and recessive models, with odds ratios of 1.35 and 1.59, respectively.
Correlation of the TCF 7 L 2 ( rs 7903146 ) polymorphism with an enhanced risk of type 2 diabetes mellitus : a meta-analysis
Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample
Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine.
Before prescribing a generic drug, detailed genotypic information with the background of ethnicity and environmental factors may be taken into consideration to be more robust in the context of personalized medicine and perhaps would cause lot less burden on the patient ensuring better management of T2D.
Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases
The possible role of ER stress in various disorders on the basis of existing literature is discussed and an attempt has been made to highlight the present knowledge which may help to elucidate and conjure basic mechanisms and novel insights into disease processes which could assist in devising better future diagnostic and therapeutic strategies.
The impact of the unfolded protein response on human disease
The unfolded protein response is an essential adaptive intracellular signaling pathway that responds to metabolic, oxidative stress, and inflammatory response pathways and is implicated in a variety of diseases including metabolic disease, neurodegenerative disease, inflammatory disease, and cancer.


Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder.
These genetic variations and linkage disequilibrium patterns in WFS1 in Japanese should be useful in further investigation of genetic diversities of W FS1 and various related disorders.
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
This study has replicated the previously reported associations between SNPs at this locus and the risk of type 2 diabetes, and performed a meta-analysis of published and previously unpublished data from Sweden, Finland and France.
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
The results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population, and the minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 1 diabetes.
Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
The previously reported protective effect of select WFS1 alleles may be magnified by a lifestyle intervention, and these variants appear to confer an improvement in beta cell function.
Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns
Evidence is found of type 2 diabetes association with SNPs in five of the six known MODY genes: GCK, H NF1A, HNF1B, NEUROD1, and HNF4A, which suggests that common variants in several MODy genes play a modest role in type 2abetes susceptibility.
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.
The results and the independent observation of association of SNPs near the P2 promoter with diabetes in a separate study population of Ashkenazi Jewish origin suggests that variant(s) located near or within HNF4A increases susceptibility to type 2 diabetes.
A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
The number of T2D loci now confidently identified to at least 10 is confirmed, and it is confirmed that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T1D risk.
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.
The aim of this study was to replicate in a Japanese population previously identified associations of single nucleotide polymorphisms within 10 candidate loci with type 2 diabetes using a relatively large sample size: 1921 subjects with type 1 diabetes and 1622 normal controls.
A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.
The associations and the partitioned linkage profiles near P2 were independently observed in a Finnish sample, suggesting the presence of potential regulatory element(s) that may contribute to the risk for type 2 diabetes.
Common variants in WFS1 confer risk of type 2 diabetes
Using a gene-centric approach, it is shown that variation in WFS1 also predisposes to common type 2 diabetes.