Corpus ID: 26035557

Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.

@article{Mita2008AssociationSO,
  title={Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.},
  author={Masaki Mita and K. Miyake and Masako Zenibayashi and Y. Hirota and T. Teranishi and K. Kouyama and K. Sakaguchi and M. Kasuga},
  journal={The Kobe journal of medical sciences},
  year={2008},
  volume={54 4},
  pages={
          E192-9
        }
}
  • Masaki Mita, K. Miyake, +5 authors M. Kasuga
  • Published 2008
  • Medicine
  • The Kobe journal of medical sciences
  • Mutations of WFS1 gene cause Wolfram syndrome, which is a rare autosomal recessive disorder characterized by juvenile diabetes mellitus, optic atrophy, deafness and diabetes insipidus. The product encoded by WFS1 gene, wolframin, could be involved in ER stress response causing beta-cell loss through impaired cell cycle progression and increased apoptosis. Recently, polymorphisms in the WFS1 gene were strongly associated with type 2 diabetes in Caucasians. The aim of the present study was to… CONTINUE READING
    9 Citations
    Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis.
    • 5
    The impact of the unfolded protein response on human disease
    • 712
    • PDF

    References

    SHOWING 1-10 OF 26 REFERENCES
    Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder.
    • 22
    • Highly Influential
    Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns
    • 84
    • PDF
    Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.
    • 263
    • PDF
    Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.
    • 133
    Common variants in WFS1 confer risk of type 2 diabetes
    • 366
    • Highly Influential
    • PDF