Corpus ID: 26035557

Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.

  title={Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.},
  author={Masaki Mita and K. Miyake and Masako Zenibayashi and Y. Hirota and T. Teranishi and K. Kouyama and K. Sakaguchi and M. Kasuga},
  journal={The Kobe journal of medical sciences},
  volume={54 4},
  • Masaki Mita, K. Miyake, +5 authors M. Kasuga
  • Published 2008
  • Medicine
  • The Kobe journal of medical sciences
  • Mutations of WFS1 gene cause Wolfram syndrome, which is a rare autosomal recessive disorder characterized by juvenile diabetes mellitus, optic atrophy, deafness and diabetes insipidus. The product encoded by WFS1 gene, wolframin, could be involved in ER stress response causing beta-cell loss through impaired cell cycle progression and increased apoptosis. Recently, polymorphisms in the WFS1 gene were strongly associated with type 2 diabetes in Caucasians. The aim of the present study was to… CONTINUE READING
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