• Corpus ID: 26035557

Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.

@article{Mita2008AssociationSO,
  title={Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.},
  author={Masaki Mita and Kazuaki Miyake and Masako Zenibayashi and Yushi Hirota and Tetsuya Teranishi and Kunichi Kouyama and Kazuhiko Sakaguchi and Masato Kasuga},
  journal={The Kobe journal of medical sciences},
  year={2008},
  volume={54 4},
  pages={
          E192-9
        }
}
Mutations of WFS1 gene cause Wolfram syndrome, which is a rare autosomal recessive disorder characterized by juvenile diabetes mellitus, optic atrophy, deafness and diabetes insipidus. The product encoded by WFS1 gene, wolframin, could be involved in ER stress response causing beta-cell loss through impaired cell cycle progression and increased apoptosis. Recently, polymorphisms in the WFS1 gene were strongly associated with type 2 diabetes in Caucasians. The aim of the present study was to… 
A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.
TLDR
Disease-associated variants of WFS1 contribute to the pathogenesis of T2D through impaired insulin response to glucose stimulation and altered β-cell function.
Association of rs 734312 and rs 10010131 polymorphisms in WFS 1 gene with type 2 diabetes mellitus : a meta-analysis
Recently, many studies have investigated the association of allelic variants of Wolfram syndrome gene (WFS1) with insulin secretion, insulin sensitivity and the risk of hyperglycemia and type 2
Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis.
TLDR
Investigation of association of WFS1 genes polymorphisms (rs734312 and rs10010131) with T2D by conducting a meta-analysis suggested that the G allele of rs734 312 polymorphism in W FS1 gene had significant protective effects on risk of T1D.
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TLDR
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TLDR
The results showed that the rs7903146 T allele of the TCF7L2 gene was positively correlated with an enhanced risk of T2DM in the allelic, heterozygote, homozygotes, dominant, and recessive models, with odds ratios of 1.35 and 1.59, respectively.
Correlation of the TCF 7 L 2 ( rs 7903146 ) polymorphism with an enhanced risk of type 2 diabetes mellitus : a meta-analysis
Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample
Genes, Genetics, and Environment in Type 2 Diabetes: Implication in Personalized Medicine.
TLDR
Before prescribing a generic drug, detailed genotypic information with the background of ethnicity and environmental factors may be taken into consideration to be more robust in the context of personalized medicine and perhaps would cause lot less burden on the patient ensuring better management of T2D.
Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases
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The possible role of ER stress in various disorders on the basis of existing literature is discussed and an attempt has been made to highlight the present knowledge which may help to elucidate and conjure basic mechanisms and novel insights into disease processes which could assist in devising better future diagnostic and therapeutic strategies.
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The unfolded protein response is an essential adaptive intracellular signaling pathway that responds to metabolic, oxidative stress, and inflammatory response pathways and is implicated in a variety of diseases including metabolic disease, neurodegenerative disease, inflammatory disease, and cancer.

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TLDR
These genetic variations and linkage disequilibrium patterns in WFS1 in Japanese should be useful in further investigation of genetic diversities of W FS1 and various related disorders.
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TLDR
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TLDR
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TLDR
Using a gene-centric approach, it is shown that variation in WFS1 also predisposes to common type 2 diabetes.
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