Association study of seven polymorphisms in four serotonin receptor genes on suicide victims

  title={Association study of seven polymorphisms in four serotonin receptor genes on suicide victims},
  author={Alja Videti{\vc} and Galina Punger{\vc}i{\vc} and Irena Zupani{\vc} Pajni{\vc} and Toma{\vz} Zupanc and Jo{\vz}e Bala{\vz}ic and Martina Tomori and Radovan Komel},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
A number of molecular genetic studies have investigated if serotonin (5‐HT) receptor subtypes are involved in the pathogenesis of depression, suicidal behavior, aggression, and impulsive behavior. Existence of many receptor subtypes for a single transmitter permits a great diversity of signaling raising the possibility that they may serve as genetic markers for suicidal behavior. Most previous studies of suicide have analyzed polymorphisms of the receptors 5‐HT1A, 5‐HT1B, 5‐HT2A, fewer have… 

Association between 5-hydroxytryptamine 1A receptor gene polymorphism and suicidal behavior.

The data support hypothesis which indicate role of the 5-HT1A C(-1019)G SNP polymorphism in elevated risk of suicidal attempt, and further studies should be performed to confirm the influence of allelic variation of serotonin receptor on elevatedrisk of auto-aggression behavior.

No association between polymorphisms in four serotonin receptor genes, serotonin transporter gene and alcohol-related suicide.

Results suggest that selected polymorphisms of the 5-HT receptor genes and transporter gene are not involved in genetic susceptibility to completed suicide under acute influence of alcohol or among alcohol-dependent individuals, but further studies in a larger sample are needed.

Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victims

This study provides no evidence for the implication of HTR1A promoter polymorphism in suicide in general, but it suggests further studies that would take into account the interconnected network of suicide completion, genetic background and stress, beside other risk factors.

Serotonergic genes and suicide: A systematic review

A Meta-Analysis of 5-Hydroxytryptamine Receptor 1B Polymorphisms With Risk of Major Depressive Disorder and Suicidal Behavior

It is identified that rs6296 and rs6298 in HTR1B may be significantly related to the risk of MDD and lethality of suicide attempts, respectively.

Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts

The findings suggest that the -1438A allele may predispose for nonimpulsive suicidal behavior, which is similar to that found in impulsive suicide attempts.

The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

The review provides converging lines of evidence that depression-related 5-HT receptors include those receptors with pro-depressive properties as well as those providing an antidepressant effect (5-HT1A, 5- HT1B, 4-HT2C subtypes).

5-HT1A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies.

A list of validated single nucleotide polymorphisms (SNPs) covering the whole gene is proposed for further investigations to make progress on consistency in 5-HT1A influence in psychiatric disorders.

Serotonin 1A receptor genetic variations, suicide, and life events in the Iranian population

The aim of the present study was to investigate the association between polymorphisms −1019C>G, 47C>T (Pro16Leu) and 815G>A (Gly272Asp) and suicidal behavior, taking into account age, gender, and the presence of stressful life and loss events in 1 year prior to suicide.



Lack of association between serotonin 5‐HT1B receptor gene polymorphism and suicidal behavior

  • D. RujescuI. GieglingTetsuya SatoH. Möller
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
It is suggested that the 5‐HT1B polymorphism is unlikely to play a major role in the genetic susceptibility to suicide attempts, and the results did not differ when the patients were divided into several subgroups.

Lack of an association between 5-HT1A receptor gene structural polymorphisms and suicide victims.

These findings suggest that neither of these two polymorphisms is associated with suicide victims and it is unlikely that the 5-HT1A receptor gene is implicated in the susceptibility to suicide.

Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder.

The results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.

Suicide and serotonin: Study of variation at seven serotonin receptor genes in suicide completers

  • G. TureckiA. Sequeira G. Rouleau
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
The results do not support a substantial role of these serotonergic receptors in suicide completion and further analysis according to suicide method or psychopathology also failed to reveal differences between groups.

Association Study of Serotonin 1B Receptor (A-161T) Genetic Polymorphism and Suicidal Behaviors and Response to Fluoxetine in Major Depressive Disorder

The findings suggest that 5-HT1B A-161T genetic polymorphism does not play a major role in the susceptibility to MDD, nor is it related to suicidal attempt or the therapeutic response to fluoxetine in MDD.

No evidence of an association between 5HT1B receptor gene polymorphism and suicide victims in a Japanese population.

These results show no evidence of an association between the 5HT1B receptor gene G861C polymorphism and suicide victims in a Japanese population and indicate that it is unlikely that the 5 HT1 B receptor is implicated in the susceptibility to suicide.

5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations.

Results did not provide supporting evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide and the proposed genetic mechanisms affecting suicidal behaviour could be related to the alterations of the genes encoding the elements of5HT synapse.

Polymorphisms of the tryptophan hydroxylase gene and serotonin 1A receptor gene in suicide victims among Japanese.

No significant relation could be established statistically concerning the serotonin related genes between the suicide samples and control samples in Akita, Japan.

Association study of novel human serotonin 5-HT1B polymorphisms with alcohol dependence in taiwanese han

Association of Serotonin 5-HT2A Receptor Binding and the T102C Polymorphism in Depressed and Healthy Caucasian Subjects

The TT genotype appears associated with higher platelet 5-HT2A Bmax in the healthy population, but this genotypic effect appears absent in mood disorders and unrelated to psychopathology.