Association study of miR-100, miR-124-1, miR-218-2, miR-301b, miR-605, and miR-4293 polymorphisms and the risk of breast cancer in a sample of Iranian population.

@article{Danesh2018AssociationSO,
  title={Association study of miR-100, miR-124-1, miR-218-2, miR-301b, miR-605, and miR-4293 polymorphisms and the risk of breast cancer in a sample of Iranian population.},
  author={H. Sopariwala Danesh and Mohammad Hashemi and Fatemeh Bizhani and Seyed Mehdi Hashemi and Gholamreza Bahari},
  journal={Gene},
  year={2018},
  volume={647},
  pages={
          73-78
        }
}
MicroRNAs (miRNAs) regulate genes expression by directly binding to the 3' untranslated region (3'UTR) of specific target mRNAs. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are proposed to be important in the development of breast cancer (BC). In the present study, we conducted a case-control study with 266 BCE patients and 288 control women to examine the possible association of miRNAs polymorphisms (miR-100 rs1834306, miR-124-1 rs531564, miR-218-2 rs11134527, miR-301b… 
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Evidence is provided that miR-1307 rs7911488 polymorphism significantly reduced the risk of BC in heterozygous AG genotype, as well as dominant (AG+GG) genotype and G allele, and that AG genotypes could increase BC’s susceptibility among the southeastern Iranian females.
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TLDR
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  • Medicine, Biology
    Oncology letters
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TLDR
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TLDR
The findings of this meta-analysis support an association between miR-124-1 rs531564 polymorphism and cancer risk and larger and well-designed studies are required to estimate this association in detail.
miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation
TLDR
The results establish oncogenic roles for both miR-4293 and WFDC21P and demonstrate that interactions between miRNAs and lncRNAs through DCP2 are important in the regulation of carcinoma pathogenesis.
Investigation of rs531564 Polymorphism in the Primary MicroRNA-124 Gene in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Association with Disease Susceptibility and Clinical Characteristics.
TLDR
A considerable association between rs531564 polymorphism in the pri-miR-124 gene with susceptibility and clinical characteristics of RA and SLE in the Iranian population is proposed.
Whether miR-4293 rs12220909 variant affects cancer susceptibility: evidence from 11255 subjects
TLDR
It is revealed that there is a significant decrease effect of miR-4293 rs12220909 to cancer risks in heterozygote genetic model, which is a protective factor to cancer initiation, especially for lung cancer.
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