Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

  title={Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD},
  author={J. Wang and Z. Liu and B. Chen},
  pages={1757 - 1759}
  • J. Wang, Z. Liu, B. Chen
  • Published 2001
  • Medicine, Biology
  • Neurology
  • The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor… CONTINUE READING
    54 Citations

    Tables and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
    • E. Tan, Yanni Tan, +8 authors Y. Zhao
    • Medicine
    • Movement disorders : official journal of the Movement Disorder Society
    • 2003
    • 28
    Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study.
    • 32
    • PDF


    Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia.
    • 75
    Short‐term levodopa test assessed by movement time accurately predicts dopaminergic responsiveness in Parkinson's disease
    • 38
    Diagnostic criteria for Parkinson disease.
    • 2,426