Association study of apolipoprotein E promoter polymorphism (-427 T/C) and Alzheimer's disease in a Tunisian population.

@article{AchouriRassas2016AssociationSO,
  title={Association study of apolipoprotein E promoter polymorphism (-427 T/C) and Alzheimer's disease in a Tunisian population.},
  author={Afef Achouri-Rassas and Nadia Ben Ali and Saloua Fray and Meriem Kechaou and N Oudiaa Zakraoui and Sondes Hadj-Fredj and Aroua Cherif and Nadia Anane and Slim Echebi and Taieb Messaoud and Samir Belal},
  journal={Revue neurologique},
  year={2016},
  volume={172 2},
  pages={127-31}
}
BACKGROUND Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an as yet poorly understood etiology. Both environmental and genetic factors have been implicated as predisposing factors. The apolipoprotein E (APOE) ɛ4 allele is an established genetic susceptibility factor for AD for several populations including the Tunisian population. Polymorphism rs769446 (-427 T/C) at the promoter region of the APOE gene is postulated to affect the expression of the gene through… CONTINUE READING
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Étude moléculaire des polymorphismes dans des gènes de l’ace et de l’apoe dans la maladie d’alzheimer chez une population tunisienne

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