Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism.

Abstract

Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the -141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 TaqI A polymorphisms in 209 Japanese alcoholics and 152 age- and sex-matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls (p < 0.002, odds ratio = 1.82). The TaqI A1 allele tended to be more frequent in the alcoholics than in the controls (p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum delta value = 0.13). The -141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese.

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@article{Ishiguro1998AssociationSB, title={Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism.}, author={Hiroki Ishiguro and Tadao Arinami and T Saito and Shigeru Akazawa and M. Enomoto and Hiroshi Mitushio and Hirohumi Fujishiro and Kohei Tada and Youichi Akimoto and Hirofumi Mifune and S Shioduka and Hideo Hamaguchi and Michio Toru and Hitoshi Shibuya}, journal={Alcoholism, clinical and experimental research}, year={1998}, volume={22 4}, pages={845-8} }