Association studies using novel polymorphisms in BACE1 and BACE2.

  title={Association studies using novel polymorphisms in BACE1 and BACE2.},
  author={P. Nowotny and Jennifer M. Kwon and Sumi Chakraverty and Volker Nowotny and John C. Morris and Alison M. Goate},
  volume={12 9},
The release of amyloid-beta peptide (Abeta) from beta-amyloid precursor protein (APP) requires cleavage by beta- and gamma-secretases. Several groups have identified a candidate for the beta-site APP-cleaving enzyme, BACE1, and its homologue BACE2. We sequenced the genes for BACE1 and BACE2 and found several polymorphisms in both genes. Genotyping a large cohort of AD cases and controls has shown no association between AD and the intronic polymorphism in BACE2 while there was a weak association… CONTINUE READING


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