Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases.

@article{Raule2007AssociationSO,
  title={Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases.},
  author={Nicola Raule and Federica Sevini and Aurelia Santoro and Serena Altilia and Claudio Franceschi},
  journal={Mitochondrion},
  year={2007},
  volume={7 1-2},
  pages={29-38}
}
Mitochondrial DNA (mtDNA) follows direct maternal inheritance and, as such, can be used in phylogenetic studies to determine a human lineage tree. The presence of common polymorphisms allows a classification of mtDNA in haplogroups and sub-haplogroups, according to the branch they belong to. Thanks to the rapidly growing number of mtDNA sequences available, this classification is being corrected and redefined to be more accurate. In parallel with this process, several studies are trying to… CONTINUE READING

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