Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

@article{Burton2007AssociationSO,
  title={Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants},
  author={Paul R. Burton and David Clayton and Lon R. Cardon and Nick Craddock and Panos Deloukas and Audrey Duncanson and Dominic P. Kwiatkowski and Mark I. McCarthy and Willem H. Ouwehand and Nilesh J. Samani and John A. Todd and Peter Donnelly and Jeffrey C. Barrett and Daniel B. Davison and Douglas Easton and David M. Evans and Hin-Tak Leung and Jonathan Marchini and Andrew P. Morris and Chris C. A. Spencer and Martin D. Tobin and Antony Paul Attwood and James P. Boorman and Barbara Cant and Ursula Everson and Judith M. Hussey and Jennifer D. Jolley and Alexandra S. Knight and Kerstin Koch and Elizabeth Meech and Sarah Nutland and Chris V Prowse and Helen E. Stevens and Niall C. Taylor and Graham R. Walters and Neil M. Walker and Nicholas Watkins and Thilo Winzer and Richard W Jones and Wendy L McArdle and Susan M. Ring and David P. Strachan and Marcus Pembrey and Gerome D. Breen and David St. Clair and Sian Caesar and Katharine Gordon-Smith and Lisa Jones and Christine Fraser and Elaine K Green and Detelina Grozeva and Marian L. Hamshere and Peter A Holmans and Ian R Jones and George Kirov and Valentina Moskivina and Ivan Nikolov and Michael C. O'Donovan and Michael J. Owen and David A. Collier and Amanda Elkin and Anne Farmer and Richard J. Williamson and Peter McGuffin and Allan H. Young and I. Nicol Ferrier and Stephen G. Ball and Anthony J. Balmforth and Jennifer H. Barrett and Tim Bishop and Mark M. Iles and Azhar Maqbool and Nadira Y. Yuldasheva and Alistair S. Hall and Peter S. Braund and Richard J. Dixon and Massimo Mangino and Suzanne E Stevens and John R. Thompson and Francesca Bredin and Mark Tremelling and Miles Parkes and Hazel E. Drummond and Charlie W. Lees and Elaine R. Nimmo and Jack Satsangi and Sheila A Fisher and Alastair Forbes and Cathryn M. Lewis and Clive M. Onnie and Natalie J. Prescott and Jeremy D Sanderson and Christopher G Matthew and Jamie A Barbour and M Khalid Mohiuddin and Catherine E Todhunter and John C Mansfield and Tariq Ahmad and Fraser Cummings and Derek P. Jewell and John Webster and Morris J. Brown and Mark G. Lathrop and John M. Connell and Anna F. Dominiczak and Carolina A. Braga Marcano and Beverley Burke and Richard J. B. Dobson and Johannie Gungadoo and Kate L. Lee and Patricia B. Munroe and Stephen Newhouse and Abiodun K Onipinla and Chris Wallace and Mingzhan Xue and Mark J. Caulfield and Martin Farrall and Anne Barton and Ian N. Bruce and Hannah Donovan and Stephen Eyre and Paul Gilbert and Samantha L Hilder and Anne Hinks and Sally L John and Catherine Potter and Alan J Silman and Deborah P M Symmons and Wendy Thomson and Jane Worthington and David B. Dunger and Barry Widmer and Timothy M. Frayling and Rachel M. Freathy and Hana Lango and John R. B. Perry and Beverley M. Shields and Michael N. Weedon and Andrew T. Hattersley and Graham A Hitman and Mark Walker and Kate S. Elliott and Christopher J. Groves and Cecilia M. Lindgren and Nigel William Rayner and Nicolas J Timpson and Eleftheria Zeggini and Melanie J. Newport and Giorgio Sirugo and Emily J. Lyons and Fredrik Vannberg and Adrian V S Hill and Linda A. Bradbury and Claire Farrar and Jennifer J. Pointon and Paul Wordsworth and Matthew A. Brown and Jayne A. Franklyn and Joanne M. Heward and Matthew J. Simmonds and Stephen C. L. Gough and Sheila Seal and Michael R. Stratton and Nazneen Rahman and Maria Ban and An Goris and Stephen J Sawcer and Alastair Compston and David J. Conway and Muminatou Jallow and Kirk A. Rockett and Suzannah J. Bumpstead and Amy Chaney and Kate Downes and Mohammed J. R. Ghori and Rhian Gwilliam and Sarah E. Hunt and Michael Inouye and Andrew Keniry and Emma V. King and Ralph McGinnis and Simon C. Potter and Rathi Ravindrarajah and Pamela Whittaker and Claire Widden and David Withers and Niall J Cardin and Teresa Ferreira and Joanne Pereira-Gale and Ingeleif B Hallgrimsdo'ttir and Bryan N. Howie and Zhan Su and Yik Ying Teo and Damjan Vukcevic and David L. Bentley and Sarah L Mitchell and Paul R. Newby and Oliver J Brand and Jackie D Carr-Smith and Simon H S Pearce and Ralph McGinnis and Andrew Keniry and Panos Deloukas and John D. Reveille and Xiaodong Zhou and A. M. Sims and Alison Dowling and Jacqueline A Taylor and T. Doan and John C. Davis and Laurie M Savage and Michael M. Ward and Thomas Learch and Michael H. Weisman and Mathew Brown},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={1329-1337}
}
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing… Expand
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