Association of yeast Upf1p with direct substrates of the NMD pathway.

@article{Johansson2007AssociationOY,
  title={Association of yeast Upf1p with direct substrates of the NMD pathway.},
  author={Marcus J O Johansson and Feng He and Phyllis Spatrick and Chunfang Li and Allan Jacobson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 52},
  pages={
          20872-7
        }
}
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades transcripts containing premature translation termination codons. Gene expression profiling experiments have shown that inactivation of the NMD pathway leads to the accumulation of both aberrant, nonsense-containing mRNAs, and many apparently wild-type transcripts. Such increases in transcript steady-state levels could arise from direct changes in the respective mRNA half-lives, or indirectly, as a… CONTINUE READING

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