Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis

@article{Chen2019AssociationOV,
  title={Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis},
  author={Heng-Gui Chen and L. Sheng and Yan-Bo Zhang and A. Cao and Y. Lai and S. Kunutsor and Limiao Jiang and A. Pan},
  journal={European Journal of Nutrition},
  year={2019},
  pages={1-15}
}
PurposeWe conducted a meta-analysis to systematically assess the prospective association between vitamin K and cardiovascular disease (CVD) events and all-cause mortality.MethodsWe searched PubMed and EMBASE through January 2019 for prospective studies that reported the association of vitamin K (assessed by dietary intake or circulating concentration) with CVD events [including total CVD, CVD mortality, total coronary heart disease (CHD), fatal CHD, nonfatal myocardial infarction (MI), and… Expand
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TLDR
Results for vitamin K2 look promising, and further prospective studies are required to confirm these findings, but currently there is no evidence for an effect of vitamin K1, but results for Vitamin K1 look promising. Expand
Vitamin K intake and all-cause and cause specific mortality.
TLDR
Vitamin K intake was not associated with all-cause mortality, cancer mortality and mortality from other causes, and none of the forms of vitamin K intake were associated with cancer mortality or mortality fromother causes. Expand
Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies
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This meta-analysis combining data from 29 prospective cohort studies demonstrated neutral associations between dairy products and cardiovascular and all-cause mortality and how dairy products can be replaced by other foods. Expand
A high menaquinone intake reduces the incidence of coronary heart disease.
TLDR
A high intake of menoquinones, especially MK-7, MK-8 and MK-9, could protect against CHD, however, more research is necessary to define optimal intake levels of vitamin K intake for the prevention of CHD. Expand
Dietary intake of vitamin K is inversely associated with mortality risk.
TLDR
An increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality in a Mediterranean population at high cardiovascular disease risk. Expand
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In observational studies, higher ALA exposure is associated with a moderately lower risk of CVD, and the high unexplained heterogeneity highlights the need for additional well-designed observational studies and large randomized clinical trials to evaluate the effects of ALA on CVD. Expand
Vitamin K intake and mortality in people with chronic kidney disease from NHANES III.
TLDR
Assessment of the relationship between vitamin K intake and mortality in patients with chronic kidney disease suggests that adequate intake of vitamin K may be associated with reduced all-cause and CVD mortality in CKD patients. Expand
Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women
TLDR
The data suggest that high phylloquinone intake may be a marker for low CHD risk, rather than intake of the nutrient itself, which might account for all or part of the weak association. Expand
Phylloquinone intake and risk of cardiovascular diseases in men.
TLDR
High phylloquinone intake may be a marker of dietary patterns associated with lower CHD risk and useful when used within that context, according to the results of a large population based study conducted in 40,087 men during 1986-2000. Expand
Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.
TLDR
It is suggested that an adequate intake of menaquinone could be important for CHD prevention and not related to any of the outcomes. Expand
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