Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis.

@article{Luotola2009AssociationOV,
  title={Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis.},
  author={Kari Luotola and Rauni P{\"a}{\"a}kk{\"o}nen and Mervi Alanne and Timo Lanki and Leena Moilanen and Ida Surakka and Arto Pietil{\"a} and Mika K{\"a}h{\"o}nen and Markku S Nieminen and Yrj{\"o} Antero Kes{\"a}niemi and Annette Peters and Antti M. Jula and Markus Perola and Veikko V Salomaa},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 11},
  pages={4575-83}
}
OBJECTIVE Proinflammatory cytokine IL-1beta is capable of decreasing insulin-induced glucose transport. Therefore, we hypothesized that genetic variation in the IL-1 gene family is associated with measures of glucose homeostasis and diabetes. DESIGN AND OUTCOME MEASURES Fifteen haplotype-tagging single-nucleotide polymorphisms in the IL-1alpha, IL-1beta, and IL-1 receptor antagonist genes were determined in a Finnish population survey (n = 6771). Glucose and insulin concentrations were… CONTINUE READING