Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

@article{VlietOstaptchouk2006AssociationOV,
  title={Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort},
  author={Jana V. van Vliet-Ostaptchouk and Ronit Shiri-Sverdlov and Alexandra Zhernakova and Eric Strengman and Timon W. van Haeften and M. H. Hofker and Cisca Wijmenga},
  journal={Diabetologia},
  year={2006},
  volume={50},
  pages={59-62}
}
A strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We aimed to replicate these findings in a Dutch cohort. We analysed the genotypes of two intronic single nucleotide polymorphisms (SNPs) in TCF7L2 gene in 502 unrelated type 2 diabetes patients and… CONTINUE READING
54 Citations
10 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 10 references

A genomewide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests existence of novel loci on 2q12 and 19q13

  • J Van Tilburg, LA Sandkuijl, E Strengman
  • J Clin Endocrin Metab
  • 2003
1 Excerpt

Measures of effect and measures of association

  • S Greenland, RK Rothman
  • Modern epidemiology, 2nd edn. Lippincott-Raven,
  • 1998

Similar Papers

Loading similar papers…