Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease.

@article{Baldassano2007AssociationOV,
  title={Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease.},
  author={Robert N Baldassano and Jonathan P. Bradfield and Dimitri S. Monos and Cecilia Kim and Joseph T. Glessner and Tracy Casalunovo and Edward C. Frackelton and Frederick G Otieno and Stathis Kanterakis and Julie L. Shaner and Ryan M. Smith and Andrew W. Eckert and Luke J. Robinson and Chioma C. Onyiah and Debra J. Abrams and Rosetta Chiavacci and Robert Skraban and Marcella Devoto and Struan F. A. Grant and Hakon Hakonarson},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2007},
  volume={5 8},
  pages={972-6}
}
BACKGROUND & AIMS Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn's disease (CD) as a consequence of a genome-wide association study of this disease in adults. We examined the effects of this and other previously reported SNPs at this locus with respect to CD in children. METHODS By using data from our ongoing genome-wide association study in our cohort of 142 pediatric CD patients and… CONTINUE READING
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