Association of tumor necrosis factor α (TNF-α) and interleukin 10 (IL-10) gene polymorphisms in dermatomyositis patients: a pilot study.

@article{Hristova2012AssociationOT,
  title={Association of tumor necrosis factor α (TNF-α) and interleukin 10 (IL-10) gene polymorphisms in dermatomyositis patients: a pilot study.},
  author={Maria Hristova and Lyubomir A Dourmishev and Zornitsa Kamenarska and Radka Kaneva and Anton Vinkov and Vanio Mitev},
  journal={Acta dermatovenerologica Croatica : ADC},
  year={2012},
  volume={20 3},
  pages={148-56}
}
TNF-α and IL-10 single nucleotide polymorphisms have been implicated in various autoimmune diseases but the results are still quite controversial. This case-control study aimed to investigate the association between six TNF-α and five IL-10 polymorphisms with dermatomyositis. The -857CC and +489GG genotypes showed a weak association with dermatomyositis when the analysis was carried out for the whole cohort but they appeared to be a significant risk factor for the development of dermatomyositis… CONTINUE READING