Association of tumor angiogenesis with bone marrow micrometastases in breast cancer patients.

@article{Fox1997AssociationOT,
  title={Association of tumor angiogenesis with bone marrow micrometastases in breast cancer patients.},
  author={StephenD. Fox and R. Leek and Judith Bliss and Janine L. Mansi and Barry Gusterson and KevinC. Gatter and Al Harris},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 14},
  pages={
          1044-9
        }
}
BACKGROUND AND PURPOSE The microscopic detection of tumor cells (micrometastases) in bone marrow and the extent of blood vessel formation (angiogenesis) in primary tumor specimens are recognized as independent prognostic markers in patients with breast cancer. Since micrometastases occur as a consequence of interaction between the neoplastic cells and the tumor neovasculature, we have examined the relationship between these markers to determine whether the degree of angiogenesis is related to… CONTINUE READING
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