Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study.

@article{Setiawan2018AssociationOT,
  title={Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study.},
  author={E. Setiawan and Sophia Attwells and Alan A. Wilson and Romina Mizrahi and Pablo M Rusjan and L. Miler and Cynthia Xu and Sarita Sharma and Stephen J. Kish and Sylvain Houle and Jeffrey H. Meyer},
  journal={The lancet. Psychiatry},
  year={2018},
  volume={5 4},
  pages={339-347}
}
BACKGROUND People with major depressive disorder frequently exhibit increasing persistence of major depressive episodes. However, evidence for neuroprogression (ie, increasing brain pathology with longer duration of illness) is scarce. Microglial activation, which is an important component of neuroinflammation, is implicated in neuroprogression. We examined the relationship of translocator protein (TSPO) total distribution volume (VT), a marker of microglial activation, with duration of… CONTINUE READING
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