Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.

  title={Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.},
  author={Laura J. Scott and Lori L. Bonnycastle and Cristen J. Willer and Andrew G. Sprau and Anne U. Jackson and Narisu Narisu and William Duren and Peter S. Chines and Heather M Stringham and Michael R Erdos and Timo T. Valle and Jaakko Tuomilehto and Richard N Bergman and Karen L. Mohlke and Francis S. Collins and Michael Boehnke},
  volume={55 9},
Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within TCF7L2 on chromosome 10q were recently reported to be associated with type 2 diabetes in Icelandic, Danish, and American (U.S.) samples. We previously observed a modest logarithm of odds score of 0.61 on chromosome 10q, approximately 1 Mb from TCF7L2, in the Finland-United States Investigation of NIDDM Genetics study. We tested the five associated TCF7L2 single nucleotide polymorphism (SNP… CONTINUE READING
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Combining multiple susceptibility polymorphisms can increase the predictive power of genetic information: a study of replicated type 2 diabetes variants [abstract online

  • A Hattersley, MN Weedon, +5 authors T Frayling
  • Available from http://…
  • 2005

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