Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma

  title={Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma},
  author={M. Linnebank and S. Moskau and A. Kowoll and A. Semmler and C. Bangard and M. Vogt-Schaden and G. Egerer and G. Schackert and H. Reichmann and I. Schmidt-Wolf and H. Pels and U. Schlegel},
  journal={British Journal of Cancer},
  pages={1840 - 1843}
  • M. Linnebank, S. Moskau, +9 authors U. Schlegel
  • Published 2012
  • Biology, Medicine
  • British Journal of Cancer
  • Background:Chemotherapy for primary central nervous system lymphoma (PCNSL) is based on methotrexate (MTX), which interferes with both nucleic acid synthesis and methionine metabolism. We have reported previously that genetic variants with influence on methionine metabolism are associated with MTX side effects, that is, the occurrence of white matter lesions as a sign of MTX neurotoxicity. Here, we investigated whether such variants are associated with MTX efficacy in terms of overall survival… CONTINUE READING
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