Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China

@article{Wu2018AssociationOT,
  title={Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China},
  author={Hongxu Wu and Bin-yan Wang and Qianyun Ban and Lulu Chen and Dong Yan and Yaren Yu and Yun Song and C Liu and Jingjing Cao and Jingping Zhang and Yuanyuan Zhang and Tao Zhang and Hao Zhang and Huiyuan Guo and Genfu Tang and Yan Zhang and Jianping Li and Yong Huo and Tonghua Zang and Xianhui Qin and Xiping Xu},
  journal={BMJ Open},
  year={2018},
  volume={8}
}
Objectives We aimed to evaluate the relation of total homocysteine (tHcy) concentrations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, and examine the possible modifiers in the association among a general population of Chinese adults. Design A cross-sectional study. Setting The study was conducted within 21 communities in Lianyungang of Jiangsu province, China. Participants A total of 26 648 participants aged ≥35 years and with no antihypertensive drug use were… 
The association between total homocysteine and blood pressure in two independent Chinese populations
TLDR
Stratified analysis showed that the association between plasma total homocysteine (tHcy) and blood pressure in two independent Chinese populations was stronger in women than in men, and in participants with tHcy ≥ 15 μmol/l than in those with t Hcy < 10  μmol/L.
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TLDR
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TLDR
The data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5- MTHFR C677T was ≤ 10 ng/mL, and this association was modified by MTHFT.
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