Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression.

@article{Song2005AssociationOT,
  title={Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression.},
  author={Fei Song and Joseph F Smith and Makoto Kimura and A D Morrow and Tomoki Matsuyama and Hiroki Nagase and William A. Held},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 9},
  pages={
          3336-41
        }
}
Early studies proposed that DNA methylation could have a role in regulating gene expression during development [Riggs, A.D. (1975) Cytogenet. Cell Genet. 14, 9-25]. However, some studies of DNA methylation in known tissue-specific genes during development do not support a major role for DNA methylation. In the results presented here, tissue-specific differentially methylated regions (TDMs) were first identified, and then expression of genes associated with these regions correlated with… CONTINUE READING

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