Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma.

@article{Kim2005AssociationOT,
  title={Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma.},
  author={Seung-Hyun Kim and Jung Hyun Choi and Hyungbin Park and John W Holloway and Seung-Koo Lee and Chitwan National Park and Heeji Shin},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2005},
  volume={35 5},
  pages={
          585-90
        }
}
BACKGROUND AND OBJECTIVE The thromboxane A2 receptor (TBXA2R) is a receptor for a potent bronchoconstrictor, TBXA2 which is known to be related to bronchial asthma and myocardial infarction. TBXA2R antagonist and TBX synthase inhibitors have been found to be effective in the management of asthmatic patients. This study was aimed to evaluate whether genetic variants of TBXA2R may be related with development of acetyl salicylic acid (ASA)-intolerant asthma (AIA). METHODS TBXA2R gene… CONTINUE READING
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