Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.

@article{Whiteway1995AssociationOT,
  title={Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.},
  author={Malcolm Whiteway and C Wu and Thomas Leeuw and Kevin P Clark and Anne Fourest-Lieuvin and David Y. Thomas and Ekkehard Leberer},
  journal={Science},
  year={1995},
  volume={269 5230},
  pages={1572-5}
}
The mating response pathway of the yeast Saccharomyces cerevisiae includes a heterotrimeric guanine nucleotide-binding protein (G protein) that activates a mitogen-activated protein MAP kinase cascade by an unknown mechanism. An amino-terminal fragment of the MAP kinase scaffold protein Ste5p that interfered with pheromone-induced cell cycle arrest was identified. A haploid-specific interaction between the amino terminus of Ste5p and the G protein beta subunit Ste4p was also detected in a two… CONTINUE READING

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