Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis.

@article{Mitchell2001AssociationOT,
  title={Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis.},
  author={Stephen Andrew Mitchell and John Grove and Anne Spurkland and Kirsten Muri Boberg and K. A. Fleming and Christopher Paul Day and Erik Schrumpf and Roger W. Chapman},
  journal={Gut},
  year={2001},
  volume={49 2},
  pages={288-94}
}
BACKGROUND AND AIMS Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) promoter genes have been described which influence expression of these cytokines. This study examines the possible association between polymorphisms at the -308 and -627… CONTINUE READING

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