Association of the tumor necrosis factor-alpha −308 G/A polymorphism with nasal polyposis

  title={Association of the tumor necrosis factor-alpha −308 G/A polymorphism with nasal polyposis},
  author={Hunkar Batikhan and Mustafa Kursat Gokcan and Esen Beder and Nejat Akar and Aysenur Ozturk and Muharrem Gerçeker},
  journal={European Archives of Oto-Rhino-Laryngology},
Nasal polyposis (NP) is a chronic inflammatory disease in which several molecular and cellular interactions play important roles. Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine with a key role in immune inflammatory responses in NP. Altered levels of TNF-α, which may occur due to polymorphisms in the TNF-α promoter region, may also be associated with NP susceptibility. Given these facts, we investigated the possible association of the TNF-α −308 G/A single nucleotide… CONTINUE READING


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