Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder.

@article{Brookes2008AssociationOT,
  title={Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder.},
  author={Keeley J. Brookes and Ziarih Hawi and Aiveen Kirley and Elijah H. Barry and Michael Gill and L Gustafson Kent},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2008},
  volume={147B 8},
  pages={
          1531-5
        }
}
Attention deficit hyperactivity disorder (ADHD) is the most common behavioral disorder affecting children worldwide. The male bias in the prevalence of the disorder, suggests that some susceptibility genes may lie on the X chromosome. In this study we present evidence for a role of the X-linked steroid sulfatase (STS) gene and neurosteroids in the development of ADHD. Previously it has been observed that probands with ADHD have lower serum concentrations of the neurosteroids DHEA, which is… CONTINUE READING
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