Association of the single nucleotide polymorphism rs599839 in the vicinity of the sortilin 1 gene with LDL and triglyceride metabolism, coronary heart disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health Study.

@article{Kleber2010AssociationOT,
  title={Association of the single nucleotide polymorphism rs599839 in the vicinity of the sortilin 1 gene with LDL and triglyceride metabolism, coronary heart disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health Study.},
  author={Marcus E. Kleber and Wilfried Renner and Tanja B. Grammer and Patrick Linsel-Nitschke and B O Boehm and Bernhard Rudolf Winkelmann and Peter Bugert and Michael Marcus Hoffmann and Winfried Maerz},
  journal={Atherosclerosis},
  year={2010},
  volume={209 2},
  pages={492-7}
}
OBJECTIVE The rs599839 polymorphism A/G in the vicinity of the sortilin 1 gene has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to further characterize the protective effect of the minor allele by analyzing the association with a variety of quantitative traits. METHODS Association of rs599839 with plasma levels of different parameters of LDL and triglyceride (TRIG) metabolism as well as the… CONTINUE READING