Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review

  title={Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review},
  author={Michael H. Bloch and Angeli Landeros-Weisenberger and Srijan Sen and Philip A. Dombrowski and Benjamin Kelmendi and Vladimir Coric and Christopher Pittenger and James Frederick Leckman},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
We investigated the association between the long (l) and short (s) alleles of the serotonin transporter polymorphism (5‐HTTLPR) in the promoter region of the SLC6A4 gene and obsessive‐compulsive disorder (OCD) using meta‐analysis to combine all published data from case–control and family based association studies (2,283 cases). In stratified meta‐analysis we investigated whether age of sample (child and adult), ethnicity (Caucasian and Asian) and study design (case–control and family‐based… 
Molecular genetics of obsessive–compulsive disorder: a comprehensive meta-analysis of genetic association studies
  • S. Taylor
  • Biology, Psychology
    Molecular Psychiatry
  • 2013
It is demonstrated that OCD is associated with multiple genes, with most having a modest association with OCD, which suggests a polygenic model of OCD, consistent with twin studies, in which multiple genes make small, incremental contributions to the risk of developing the disorder.
Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.
Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population
Genetic variation in the SLC6A4 gene regulatory region may not have a significant effect on OCD in the present population of OCD patients and controls of south Indian origin.
Lack of Evidence For Association Between Serotonin Transporter Gene Polymorphism and Obsessive Compulsive Disorder fienel
The authors could not find any evidence for the association of 5-HTTLPR and 5- HTT VNTR polymorphisms with OCD, response to treatment with serotonin reuptake inhibitors, positive family history for OCD and presence of tics.
Is serotonin transporter polymorphism (5-HTTLPR) allele status a predictor for obsessive-compulsive disorder? A meta-analysis
The findings provide further support for the need of subtype classification of this heterogeneous disorder and emphasis should be placed on the effect of female reproductive milestones on OCD onset and symptom exacerbation.
Association of the functional serotonin transporter haplotype with familial form of obsessive compulsive disorder in Iranian patients
The association of SLC6A4 variants with familial form of OCD was showed and proposed stratified analyses in the genetic studies facilitate identification of genetic risk factors for this heterogeneous disorder.
Association of SLC6A4 variants with obsessive-compulsive disorder in a large multi-center US family study
Evidence is found of genetic association at the SLC6A4 locus with OCD using the Family-Based Association Test (FBAT) under additive, dominant, recessive and genotypic models, using both OCD and sex-stratified OCD as phenotypes.
Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder
The findings suggest that the high-expressing variant of 5-HTTLPR polymorphism may be associated with lower performance on some abstraction and planning measures in OCD patients.
Sex determines which section of the SLC6A4 gene is linked to obsessive-compulsive symptoms in normal Chinese college students.


Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder
  • Pao-Yen Lin
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2007
Association study of the serotonin transporter gene polymorphism in obsessive-compulsive disorder.
Haplotype-based haplotype relative risk and transmission disequilibrium analysis did not show a preferential transmission of l allele to OCD probands, indicating the need to analyse larger samples using family-based methods.
Association Studies of Serotonin System Candidate Genes in Early-onset Obsessive-Compulsive Disorder
Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits
  • S. Sen, M. Burmeister, D. Ghosh
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2004
There is a strong association between the serotonin transporter promoter variant and neuroticism as measured in the NEO personality inventory and that non‐replications are largely due to small sample size and the use of different inventories.
Obsessive-compulsive disorder and the promoter region polymorphism (5-HTTLPR) in the serotonin transporter gene (SLC6A4): a negative association study in the Afrikaner population.
Evidence that variation in SLC6A4 plays a significant role in the development of OCD in the population groups studied is inconclusive, and future association studies in Caucasian populations may extend the power of such meta-analyses and assist in delineating the role of SLC 6A4 in OCD.
Meta‐analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
  • R. Feinn, M. Nellissery, H. Kranzler
  • Biology, Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
Allelic variation at 5‐HTTLPR contributes to risk for AD, with the greatest effect observed among individuals with a co‐occurring clinical feature.
Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved
Obsessive-Compulsive Disorder, Factor-Analyzed Symptom Dimensions and Serotonin Transporter Polymorphism
The SERTPR polymorphisms affect certain factors of OC symptoms, and the factor analytic approach used in the present study has identified meaningful symptom dimensions to help guide future research.