Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion.

@article{Yu2009AssociationOT,
  title={Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion.},
  author={I-M Yu and Heather A. Holdaway and Paul R. Chipman and Richard J. Kuhn and Michael G. Rossmann and J Chen},
  journal={Journal of virology},
  year={2009},
  volume={83 23},
  pages={12101-7}
}
Flavivirus assembles into an inert particle that requires proteolytic activation by furin to enable transmission to other hosts. We previously showed that immature virus undergoes a conformational change at low pH that renders it accessible to furin (I. M. Yu, W. Zhang, H. A. Holdaway, L. Li, V. A. Kostyuchenko, P. R. Chipman, R. J. Kuhn, M. G. Rossmann, and J. Chen, Science 319:1834-1837, 2008). Here we show, using cryoelectron microscopy, that the structure of immature dengue virus at pH 6.0… CONTINUE READING

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