Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer.

@article{Jensen2008AssociationOT,
  title={Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer.},
  author={Martin Blomberg Jensen and Henrik Christian Leffers and J\orgen Holm Petersen and Gedske Daugaard and Niels Erik Skakkebaek and Ewa Rajpert-De Meyts},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2008},
  volume={19 11},
  pages={1910-4}
}
BACKGROUND A possible association between the polymorphic CAG repeat in the DNA polymerase gamma (POLG) gene and the risk of testicular germ-cell tumours (TGCT) was investigated in this study. The hypothesis was prompted by an earlier preliminary study proposing an association of the absence of the common 10-CAG-long POLG allele with testicular cancer as well as previously reported in some European populations' association with male subfertility, which is a condition carrying an increased risk… CONTINUE READING

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