Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.

@article{Falcone2011AssociationOT,
  title={Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.},
  author={Mary Falcone and C. H. Jepson and Neal Benowitz and Andrew Bergen and Angela G Pinto and E. Paul Wileyto and Don A Baldwin and Rachel F. Tyndale and Caryn Lerman and Riju Ray},
  journal={Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco},
  year={2011},
  volume={13 6},
  pages={498-503}
}
INTRODUCTION Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking. The nicotine metabolite ratio (NMR), a measure of the rate of nicotine metabolism, is associated with the number of cigarettes per day (CPD) and likelihood of cessation. We tested the potential interacting effects of these two risk factors on CPD. METHODS Pretreatment data from three prior clinical trials were pooled for analysis. One… CONTINUE READING

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