Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy.

@article{Sookoian2008AssociationOT,
  title={Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy.},
  author={Silvia Sookoian and Gustavo O. Casta{\~n}o and Adriana Laura Burgue{\~n}o and Tom{\'a}s Fern{\'a}ndez Gianotti and Carlos J Pirola},
  journal={Journal of hepatology},
  year={2008},
  volume={48 1},
  pages={
          125-32
        }
}
BACKGROUND/AIMS We hypothesized that common genetic variation at ABCC2 influences ICP susceptibility. Hence we studied the association of single nucleotide polymorphisms (SNPs) of promoter, coding and non-coding regions of ABCC2 and intrahepatic cholestasis of pregnancy (ICP). METHODS 70 ICP patients and 112 healthy pregnant women in the third trimester of their pregnancies were included in a cross sectional study. Four tag SNPs (rs717620 A/G; rs2756105 C/T; rs2002042 C/T; rs3740066 A/G… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

New molecular insights into the mechanisms of cholestasis.

  • Journal of hepatology
  • 2009
VIEW 16 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Nuclear receptor ligands in therapy of cholestatic liver disease.

  • Frontiers in bioscience
  • 2009
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Pregnancy and bile acid disorders.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND