Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia.

@article{Yoshimura2000AssociationOT,
  title={Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia.},
  author={Takazumi Yoshimura and Michihiro Yoshimura and Ai Tabata and Yukio Shimasaki and Masafumi Nakayama and Yoshihiro Miyamoto and Yoshihiko Saito and Kazuwa Nakao and Hirofumi Yasue and Hitoshi Okamura},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2000},
  volume={7 4},
  pages={238-41}
}
OBJECTIVES A large number of studies suggest that abnormalities in nitric oxide (NO) synthesis may contribute to the development of preeclampsia. We recently identified a variant within exon 7 of the endothelial NO synthase (eNOS) gene: G to T conversion at nucleotide position 894 resulting in replacement of glutamic acid with aspartic acid at codon 298… CONTINUE READING