Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.

@article{Shimasaki1998AssociationOT,
  title={Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.},
  author={Yukio Shimasaki and Hirofumi Yasue and Michihiro Yoshimura and Masafumi Nakayama and Kiyotaka Kugiyama and Hisashi Ogawa and Eisaku Harada and Takaaki Masuda and Wasaku Koyama and Yoshihiko Saito and Yoshihiro Miyamoto and Yasuhiro Ogawa and Kazuwa Nakao},
  journal={Journal of the American College of Cardiology},
  year={1998},
  volume={31 7},
  pages={
          1506-10
        }
}
OBJECTIVES We examined the possible association between the missense Glu298Asp variant of the endothelial nitric oxide synthase (eNOS) gene and myocardial infarction (MI). BACKGROUND Endothelium-derived nitric oxide (NO) plays a key role in the regulation of vascular tone. Recently, we reported that a missense Glu298Asp variant in exon 7 of the eNOS gene is a possible genetic factor involved in the pathogenesis of coronary spasm. Endothelium-derived NO also has vasoprotective effects by… CONTINUE READING
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