Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.

@article{Jeon2013AssociationOT,
  title={Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.},
  author={Young Joo Jeon and Ok Joon Kim and Su Yeoun Kim and Seung Hun Oh and Doyeun Oh and Ok Jun Kim and Byoung Soo Shin and Nam Keun Kim},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 2},
  pages={420-30}
}
OBJECTIVE MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. METHODS AND RESULTS Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 patients with ischemic stroke, 373 patients with SBI, and 553 control subjects. The miR-146aC>G… CONTINUE READING

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