Association of the macrophage migration inhibitory factor −173*C allele with childhood nephrotic syndrome

@article{Vivarelli2007AssociationOT,
  title={Association of the macrophage migration inhibitory factor −173*C allele with childhood nephrotic syndrome},
  author={Marina S. Vivarelli and Leila Emma D’Urbano and Gilda Rita Stringini and Gian Marco Ghiggeri and Gianluca Caridi and Rachelle P. Donn and Alberto Enrico Tozzi and Francesco Emma and Fabrizio de Benedetti},
  journal={Pediatric Nephrology},
  year={2007},
  volume={23},
  pages={743-748}
}
Macrophage migration inflammatory factor (MIF) is a proinflammatory cytokine with a unique role as the physiologic counterregulator of the immunosuppressive effects of glucocorticoids. MIF has been implicated in the pathogenesis of glomerular inflammation. The MIF promoter contains a G/C polymorphism that is functionally relevant, with the C allele being associated with higher MIF production and linked to susceptibility to inflammatory diseases. We genotyped the MIF −173 polymorphism in 257… CONTINUE READING